Back to search

Article

Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis

2025-08-19

Abstract excerpt

<title>Abstract</title> <p>Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipogenesis, but the mechanisms underlying its strong induction in response to adipogenic cues are poorly understood. Using human mesenchymal stem cells as a model system, we show that the PPARG locus is primed for activation in the progenitor state by a highly connected enhancer community, which gets furth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8c605dda-cccb-540b-87f7-4b65484bb350
DOI
10.21203/rs.3.rs-6466826/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Extensive enhancer crosstalk controls PPARG2 activation during adipogenesisDOI 10.21203/rs.3.rs-6466826/v1
Rewiring of chromatin loops in adipogenesis reveals targets for obesity and diabetes interventionSemantic proximity
Single-cell multiomics reveals multiple adipogenic pathways and diverse multilineage specializations during embryonic fat tail morphogenesisSemantic proximity
Transcriptional and Epigenomic Regulation of AdipogenesisSemantic proximity
PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative IsoformsSemantic proximity
A chromatin perspective of adipogenesisSemantic proximity
Epigenetic regulation of adipogenesis.Semantic proximity
Genetic and epigenetic regulation of PPARγ during adipogenesis.Semantic proximity
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS.Semantic proximity
Systematic dissection of genomic features determining transcription factor binding and enhancer function.Semantic proximity
Transcriptional and epigenetic regulation of PPARγ expression during adipogenesisSemantic proximity
Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory networkSemantic proximity
Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and PathwaysSemantic proximity
Select a neighboring publication to make it the new centre.