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Article

Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest.

Journal of human genetics - 1 Jan 2006

Sato Hisashi, Miyamoto Toshinobu, Yogev Leah, Namiki Mikio, Koh Eitesu, Hayashi Hiroaki, Sasaki Yoshihito, Ishikawa Mutsuo, Lamb Dolores J, Matsumoto Naomichi, Birk Ohad S, Niikawa Norio, Sengoku Kazuo

Abstract excerpt

Genetic mechanisms are implicated as a cause of some male infertility, yet are poorly understood. Mouse meiotic mutant mei1 (meiosis defective 1) was isolated by a screening of infertile mice. Male mei1 mice have azoospermia due to meiotic arrest, and the mouse Mei1 gene is responsible for the mei1 phenotype. To investigate whether human MEI1 gene defects are associated with azoospermia by meiotic arrest, we...

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Identifiers

PMID: 16683055
DOI: 10.1007/s10038-006-0394-5

Genes

MEI1

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Related research

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Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest.PMID 16683055Read ↗

Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertilitySemantic proximity Read ↗

Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility.Semantic proximity Read ↗

Novel variants in MEI1 cause female infertility characterized by early embryonic arrest and implantation failure.Semantic proximity Read ↗

Bi-allelic MEI1 variants cause meiosis arrest and non-obstructive azoospermiaSemantic proximity Read ↗

Biallelic mutations in <i>M1AP</i> are a frequent cause of meiotic arrest leading to male infertilitySemantic proximity Read ↗

A common cause of non-obstructive azoospermia: biallelic MEI1 variants and implications for infertility diagnostics.Semantic proximity Read ↗

A new MEIOB mutation is a recurrent cause for azoospermia and testicular meiotic arrestSemantic proximity Read ↗

Novel biallelic mutations in MEI1: expanding the phenotypic spectrum to human embryonic arrest and recurrent implantation failure.Semantic proximity Read ↗

Novel MEI1 mutations cause chromosomal and DNA methylation abnormalities leading to embryonic arrest and implantation failure.Semantic proximity Read ↗

Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.Semantic proximity Read ↗

Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients.Semantic proximity Read ↗

Novel MEIOB pathogenic variants including a homozygous non-canonical splicing variant, cause meiotic arrest and human non-obstructive azoospermia.Semantic proximity Read ↗

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