Article
A common cause of non-obstructive azoospermia: biallelic MEI1 variants and implications for infertility diagnostics.
Journal of assisted reproduction and genetics - 1 Apr 2026
Tan Chen, Wang Tiantian, Tu Chaofeng, Xie Chunbo, Chen Zixu, Yuan Shimin, Hu Tongyao, He Wenbin, Li Yong, Wang Yurong, Luo Chen, Zhang Qianjun, Nie Hongchuan, Zhang Huan, Lu Guangxiu, Lin Ge, Tan Yue-Qiu, Meng Lanlan, Du Juan
Abstract excerpt
PURPOSE: Infertility affects about 15% of couples globally, with genetic factors contributing significantly. Advances in genomic technologies have led to the discovery of genes like MEI1, which play a crucial role in meiosis. However, the population prevalence and pathological mechanisms of human MEI1 variants remains poorly defined. METHODS: To elucidate the contribution of MEI1 to spermatogenic failure, initial...
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