Article

Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEM

2020-05-03

Abstract excerpt

Cryo-electron microscopy of protein complexes often leads to moderate resolution maps (4-8 Å), with visible secondary structure elements but poorly resolved loops, making model-building challenging. In the absence of high-resolution structures of homologues, only coarse-grained structural features are typically inferred from these maps, and it is often impossible to assign specific regions of density to individual...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6972690f-7b98-5220-ae46-e1ae7a2d6e36
DOI: 10.1101/2020.05.01.072751

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEMDOI 10.1101/2020.05.01.072751Read

Automated model building and protein identification in cryo-EM mapsSemantic proximity Read

CryoPhold: CryoEM meets AlphaFold and molecular simulation to reveal protein dynamicsSemantic proximity Read

Human mitochondrial protein complexes revealed by large-scale coevolution analysis and deep learning-based structure modelingSemantic proximity Read

Deep Local Analysis deconstructs protein-protein interfaces and accurately estimates binding affinity changes upon mutation.Semantic proximity Read

Machine learning of three-dimensional protein structures to predict the functional impacts of genome variationSemantic proximity Read

ParSeek: Accurate cryo-EM particle picking with a deep learning model trained on synthetic dataSemantic proximity Read

Machine Learning of Three-Dimensional Protein Structures to Predict the Functional Impacts of Genome Variation.Semantic proximity Read

The Evolution of the AlphaFold ArchitectureSemantic proximity Read

Sampling native-like structures of RNA-protein complexes through Rosetta folding and dockingSemantic proximity Read

DirectContacts2: A network of direct physical protein interactions derived from high-throughput mass spectrometry experimentsSemantic proximity Read

Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.Semantic proximity Read

Towards a structurally resolved human protein interaction network.Semantic proximity Read