Article

TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

2024-01-22

Abstract excerpt

Transmembrane channel-like (TMC) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 are components of the mechanotransduction channel in hair cells, and mutations of TMC1/2 cause deafness in humans and mice. However, the physiological roles of other TMC proteins remain largely unknown. Here, we show that Tmc7 is specifically expressed in the testis and th...

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Literature Corpus work: 8c222ba9-40c1-58c1-ae2c-a4b8b618a461
DOI: 10.1101/2024.01.18.576276

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