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Article

Loss of the Na+/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation

6 May 2017

Abstract excerpt

Mammalian sperm feature a specialized secretory organelle on the anterior part of the sperm nucleus, the acrosome, which is essential for male fertility. It is formed by a fusion of Golgi-derived vesicles. We show here that the predominantly Golgi-resident Na + /H + exchanger NHE8 localizes to the developing acrosome of spermatids. Similar to wild-type mice, Nhe8 −/− mice generated Golgi-derived vesicles positive...

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PMID: 28476888
DOI: 10.1074/jbc.m117.784108

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