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Article

CCDC157 is essential for sperm differentiation and shows oligoasthenoteratozoospermia-related mutations in men.

Journal of cellular and molecular medicine - 1 Apr 2024

Zheng Huimei, Gong Chenjia, Li Jingping, Hou Jiaru, Gong Xinhan, Zhu Xinhai, Deng Huan, Wu Haoyue, Zhang Fengbin, Shi Qinghua, Zhou Jianteng, Shi Baolu, Yang Xiaohang, Xi Yongmei

Abstract excerpt

Oligoasthenoteratospermia (OAT), characterized by abnormally low sperm count, poor sperm motility, and abnormally high number of deformed spermatozoa, is an important cause of male infertility. Its genetic basis in many affected individuals remains unknown. Here, we found that CCDC157 variants are associated with OAT. In two cohorts, a 21-bp (g.30768132_30768152del21) and/or 24-bp (g.30772543_30772566del24)...

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Identifiers

PMID: 38509755
DOI: 10.1111/jcmm.18215
PMCID: PMC10955179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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