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Genotype-Specific Electrophysiological Remodeling in PLN R14del Cardiomyopathy: Implications for Precision Antiarrhythmic Therapy.

Circulation. Arrhythmia and electrophysiology - 1 Aug 2026

Abdelsayed Mena Fawzy, Gianitsos Efthimios Tim, Yu Alice, Mercola Mark

Abstract excerpt

BACKGROUND: Inherited PLN (phospholamban) R14del variants cause dilated cardiomyopathy with a high burden of malignant ventricular arrhythmias. However, the single-cell electrophysiological substrate underlying arrhythmogenicity is incompletely characterized, and it is unclear whether antiarrhythmic agents validated in wild-type (WT) or long QT models retain efficacy in this genotype. We sought to define the...

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Anti-Arrhythmia Agents
Arrhythmias, Cardiac
Cardiomyopathy, Dilated
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Induced Pluripotent Stem Cells

Myocytes, Cardiac

Precision Medicine

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Identifiers

PMID: 42417031
DOI: 10.1161/CIRCEP.125.014684

Genes

PLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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