Article

Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition

2020-10-21

Abstract excerpt

Neuromuscular junctions (NMJs) ensure proper communication between motor neurons and muscle through the release of neurotransmitters. In motor neuron disorders, such as amyotrophic lateral sclerosis (ALS), NMJs degenerate resulting in muscle atrophy, paralysis and respiratory failure. The aim of this study was to establish a versatile and reproducible in vitro model of a human motor unit to study the effect of AL...

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Literature Corpus work: 8c1cba2b-5442-5854-a593-e0c6fd5f15c5
DOI: 10.1101/2020.10.21.346874

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