Back to search

Article

Oral administration of dibenzoylmethane (DBM) prevents cognitive decline in a C9ORF72-mediated FTD mouse model

2026-08-10

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related neurodegenerative disorders that display overlapping features. The hexanucleotide repeat expansion GGGGCC (G 4 C 2 ) in the C9ORF72 gene is the most common cause of ALS and FTD, which results in the accumulation of dipeptide-repeat protein aggregates. Regulation of protein synthesis at the level of the initiation factor eIF2α...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3fab8f2e-7f66-5d0d-8d73-cbbd3df19b9b
DOI
10.64898/2026.08.07.743573
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Oral administration of dibenzoylmethane (DBM) prevents cognitive decline in a C9ORF72-mediated FTD mouse modelDOI 10.64898/2026.08.07.743573
Diazoxide/dibenozylmethane treatment mitigates spatial memory deficits and pathology and upregulates protective genes in an Alzheimer’s transgenic rat modelSemantic proximity
BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD modelSemantic proximity
The Development of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia DisordersSemantic proximity
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.Semantic proximity
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G 4 C 2 ) repeat expansion in vitro and in vivo ALS modelsSemantic proximity
Genetic reduction of the translational repressors FMRP and 4E-BP2 preserves memory in mouse models of Alzheimer’s diseaseSemantic proximity
Dietary Non-protein Amino Acid AZE as an Environmental Trigger Activating Latent Genetic Susceptibility in <i>C9orf72</i> -ALS PathogenesisSemantic proximity
A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypesSemantic proximity
A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.Semantic proximity
Inducible expression of human <i>C9ORF72</i> 36x G <sub>4</sub> C <sub>2</sub> hexanucleotide repeats is sufficient to cause RAN translation and rapid muscular atrophy in miceSemantic proximity
Bromodomain inhibitors regulate the C9ORF72 locus in ALS.Semantic proximity
Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy.Semantic proximity
Select a neighboring publication to make it the new centre.