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Article

Expression of yeast NDI1 rescues a Drosophila complex I assembly defect.

PloS one - 1 Jan 2012

Cho Jaehyoung, Hur Jae H, Graniel Jacqueline, Benzer Seymour, Walker David W

Abstract excerpt

Defects in mitochondrial electron transport chain (ETC) function have been implicated in a number of neurodegenerative disorders, cancer, and aging. Mitochondrial complex I (NADH dehydrogenase) is the largest and most complicated enzyme of the ETC with 45 subunits originating from two separate genomes. The biogenesis of complex I is an intricate process that requires multiple steps, subassemblies, and assembly...

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Identifiers

PMID: 23226344
DOI: 10.1371/journal.pone.0050644
PMCID: PMC3511326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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