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Article

Fibrillarin modulates fetal hemoglobin silencing

2024-06-25

Abstract excerpt

Decoding the molecular mechanisms underlying human fetal (γ) globin gene silencing impacts therapeutic strategies for β-thalassemia and sickle cell disease. Here, we identified a nucleolar protein, fibrillarin (FBL), which mediates the methylation of glutamine104 in histone H2A and functions as a repressor of the γ-globin gene in cultured erythroid cells, including those from β-thalassemia patients. Conditional F...

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Literature Corpus work
8bdd8343-0807-5bcb-9f23-b21505acfc54
DOI
10.1101/2024.06.25.600532
Open publication

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Fibrillarin modulates fetal hemoglobin silencingDOI 10.1101/2024.06.25.600532
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