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Article

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells

27 Feb 2013

Abstract excerpt

An understanding of the human fetal to adult hemoglobin switch offers the potential to ameliorate β-type globin gene disorders such as sickle cell anemia and β-thalassemia through activation of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD, play a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD complexes. We observed that...

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Share to Epigenetics and DNA Methylation
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PMID: 23444401
DOI: 10.1182/blood-2012-11-466227

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