Article
Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age.
Diabetes - 1 May 2022
Marino Fabiola, Scalise Mariangela, Salerno Nadia, Salerno Luca, Molinaro Claudia, Cappetta Donato, Torella Michele, Greco Marta, Foti Daniela, Sasso Ferdinando C, Mastroroberto Pasquale, De Angelis Antonella, Ellison-Hughes Georgina M, Sampaolesi Maurilio, Rota Marcello, Rossi Francesco, Urbanek Konrad, Nadal-Ginard Bernardo, Torella Daniele, Cianflone Eleonora
Abstract excerpt
Diabetes mellitus (DM) affects the biology of multipotent cardiac stem/progenitor cells (CSCs) and adult myocardial regeneration. We assessed the hypothesis that senescence and senescence-associated secretory phenotype (SASP) are main mechanisms of cardiac degenerative defect in DM. Accordingly, we tested whether ablation of senescent CSCs would rescue the cardiac regenerative/reparative defect imposed by DM. We...
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