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Article

Senescence mechanisms and targets in the heart

5 May 2021

Abstract excerpt

Cellular senescence is a state of irreversible cell cycle arrest associated with ageing. Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarction, and cardiac fibrosis. While age-related telomere shortening represents a major cause of replicative senescence, the senescent state can also be induced by oxidative...

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PMID: 33963378
DOI: 10.1093/cvr/cvab161

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