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PHGDH Acts as an Oncogenic Accelerator by Activating the c-MYC/CDK2 Axis to Drive Cell Cycle Progression in Endometrial Cancer

2026-07-09

Abstract excerpt

<title>Abstract</title> <p> Endometrial cancer (EC) is one of the most prevalent gynecological tumors with rising incidence and mortality rates <sup>[1]</sup> . Phosphoglycerate dehydrogenase (PHGDH), a key enzyme in serine biosynthesis, is closely related to the progression of various cancers, yet its role in EC pathogenesis remains poorly understood. Immunohistochemistry was used to detect the PHGDH expressi...

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Literature Corpus work
9ae18849-ca09-5ca6-948b-4a7e80343d28
DOI
10.21203/rs.3.rs-9566244/v1
Open publication

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PHGDH Acts as an Oncogenic Accelerator by Activating the c-MYC/CDK2 Axis to Drive Cell Cycle Progression in Endometrial CancerDOI 10.21203/rs.3.rs-9566244/v1
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