Article

Disrupted Autophagy and Neuronal Dysfunction in <i>C. elegans</i> Knock-in Models of FUS Amyotrophic Lateral Sclerosis

2019-10-11

Abstract excerpt

It remains unclear how mutations in FUS, a ribonucleoprotein, lead to neuronal dysfunction in Amyotrophic Lateral Sclerosis (ALS) patients. To examine mechanisms underlying ALS FUS dysfunction, we generated the first C. elegans knock-in models using CRISPR/Cas9-mediated genome editing, creating R524S and P525L ALS FUS models. Although FUS inclusions were not detected, ALS FUS animals showed defective neuromuscula...

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Literature Corpus work: 3f7a8bd6-bff6-5a0a-bb17-ea1058d57dfd
DOI: 10.1101/799932

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