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Article

Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.

Scientific reports - 30 Jun 2021

Salam Shaakir, Tacconelli Sara, Smith Bradley N, Mitchell Jacqueline C, Glennon Elizabeth, Nikolaou Nikolas, Houart Corinne, Vance Caroline

Abstract excerpt

Aberrantly expressed fused in sarcoma (FUS) is a hallmark of FUS-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Wildtype FUS localises to synapses and interacts with mitochondrial proteins while mutations have been shown to cause to pathological changes affecting mitochondria, synapses and the neuromuscular junction (NMJ). This indicates a crucial physiological role for FUS in...

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Source

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Identifiers

PMID: 34193962
DOI: 10.1038/s41598-021-93189-6
PMCID: PMC8245466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.PMID 34193962Read ↗

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