Article

Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates

2023-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that resulted in more than 6-million deaths worldwide. The virus encodes several non-structural proteins (Nsps) that contain elements capable of disrupting cellular processes. Among these Nsp proteins, Nsp3 contains macrodomains, e.g., Mac1, Mac2, Mac3, with potential effects on host cells. Mac1 has...

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Literature Corpus work: 8b9a5aeb-9500-5918-ab1d-326297d5806d
DOI: 10.1101/2023.02.07.527501

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