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Article

The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation.

Viruses - 31 Mar 2020

Alhammad Yousef M O, Fehr Anthony R

Abstract excerpt

Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection. ADP-ribose is covalently attached to target proteins by poly-ADP-ribose polymerases (PARPs), using nicotinamide adenine dinucleotide (NAD+) as a substrate. This modification can have a wide variety of effects on proteins...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32244383
DOI: 10.3390/v12040384
PMCID: PMC7232374

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