Article
Shared epithelial pathways to lung repair and disease.
European respiratory review : an official journal of the European Respiratory Society - 30 Jun 2017
Spella Magda, Lilis Ioannis, Stathopoulos Georgios T
Abstract excerpt
Chronic lung diseases present tremendous health burdens and share a common pathobiology of dysfunctional epithelial repair. Lung adenocarcinoma, the leading cancer killer worldwide, is caused mainly by chemical carcinogens of tobacco smoke that induce mutations in pulmonary epithelial cells leading to uncontrolled epithelial proliferation. Lung epithelial cells that possess the capacity for self-renewal and...
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