Article

A combination of Interferon Stimulated Genes is more effective than IFNα and IFNβ in reducing HIV-1 replication in human cervicovaginal tissues

2019-04-16

Abstract excerpt

Enhancing antiviral responses while controlling immune cell activation is an attractive strategy to reduce HIV-1 replication in the cervicovaginal mucosae, a primary site of heterosexual transmission. Interferon alpha and beta (IFNα/β) signaling up-regulates expression of inflammatory factors and Interferon-Stimulated Genes (ISGs). The simultaneous induction of both IFNs by pathogen-bound molecular pattern recogni...

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Literature Corpus work: 8b779948-aad7-54d7-a87f-5931aad0d9df
DOI: 10.1101/610964

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