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Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins

22 Oct 2015

Abstract excerpt

UNLABELLED: High-risk human papillomaviruses (hr-HPV) establish persistent infections in keratinocytes, which can lead to cancer of the anogenital tract. Interferons (IFNs) are a family of secreted cytokines that induce IFN-stimulated genes (ISGs), many of which display antiviral activities. Transcriptome studies have indicated that established hr-HPV-positive cell lines display a reduced expression of ISGs,...

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PMID: 26491169
DOI: 10.1128/jvi.02137-15

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