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Article

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

1 May 2016

Abstract excerpt

Despite their antiviral effect, the in vivo effect of interferons on HIV transmission is difficult to predict, because interferons also activate and recruit HIV-susceptible cells to sites of infection. HIV does not normally induce type I interferons in infected cells, but does if TREX1 is knocked down. Here, we investigated the effect of topical TREX1 knockdown and local interferon production on HIV transmission...

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PMID: 27184854
DOI: 10.1016/j.celrep.2016.04.048

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