Article

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

2023-08-09

Abstract excerpt

Structural resolution of protein interactions enables mechanistic and functional studies as well as interpretation of disease variants. However, structural data is still missing for most protein interactions because we lack computational and experimental tools at scale. We thoroughly assessed AlphaFold-Multimer accuracy for structure prediction of interactions involving folded domains binding to short linear motif...

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Literature Corpus work: 8b397cdb-6165-5895-8e5c-caa697616e58
DOI: 10.1101/2023.08.07.552219

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