Article

Resolving Immune Lineage and Cell-State Heterogeneity in Human PBMCs via Mass Spectrometry-Based Single-Cell Proteomics

2026-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell proteomics (SCP) currently lacks validated benchmarking standards, and cell annotation often relies on transcriptomic proxies. Unsupervised clustering offers a proxy-free alternative, but its success depends on biological signal outweighing technical variation. In homogeneous samples this is achievable, but in heterogeneous populations, where closely related cell types differ only su...

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Literature Corpus work: 8b11bf1a-38bc-52ef-851b-42cb2056d38c
DOI: 10.64898/2026.07.29.741525

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