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Integrated RNA and DNA sequencing improves mutation detection in low purity tumors

26 Jun 2014

Abstract excerpt

Identifying somatic mutations is critical for cancer genome characterization and for prioritizing patient treatment. DNA whole exome sequencing (DNA-WES) is currently the most popular technology; however, this yields low sensitivity in low purity tumors. RNA sequencing (RNA-seq) covers the expressed exome with depth proportional to expression. We hypothesized that integrating DNA-WES and RNA-seq would enable...

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PMID: 24970867
DOI: 10.1093/nar/gku489

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