Article

A target expression threshold dictates invader defense and autoimmunity by CRISPR-Cas13

2021-11-23

Abstract excerpt

<h4>SUMMARY</h4> Immune systems must recognize and clear foreign invaders without eliciting autoimmunity. CRISPR-Cas immune systems in prokaryotes manage this task by following two criteria: extensive guide:target complementarity and a defined target-flanking motif. Here we report an additional requirement for RNA-targeting CRISPR-Cas13 systems: expression of the target transcript exceeding a threshold. This find...

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Literature Corpus work: 8afe7606-762f-5df7-8f7d-1de2d1f8e8ab
DOI: 10.1101/2021.11.23.469693

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