Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cas9 interaction with the tracrRNA nexus modulates the repression of type II-A CRISPR-cas genes.

Nucleic acids research - 23 Sept 2024

Kim Hyejin, Marraffini Luciano A

Abstract excerpt

Immune responses need to be regulated to prevent autoimmunity. CRISPR-Cas systems provide adaptive immunity in prokaryotes through the acquisition of short DNA sequences from invading viruses (bacteriophages), known as spacers. Spacers are inserted into the CRISPR locus and serve as templates for the transcription of guides used by RNA-guided nucleases to recognize complementary nucleic acids of the invaders and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages
Share to CRISPR-Associated Protein 9
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Mutation

Share to Promoter Regions, Genetic

Share to RNA, Guide, CRISPR-Cas Systems

Source

Open in PubMed Open full text

Identifiers

PMID: 38994567
DOI: 10.1093/nar/gkae597
PMCID: PMC11417352

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cas9 interaction with the tracrRNA nexus modulates the repression of type II-A CRISPR-cas genes.PMID 38994567Read ↗

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression.Semantic proximity Read ↗

Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response.Semantic proximity Read ↗

CRISPR-Cas Systems: A Functional Perspective and InnovationsSemantic proximity Read ↗

DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes.Semantic proximity Read ↗

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli.Semantic proximity Read ↗

CRISPR/Cas, the immune system of bacteria and archaea.Semantic proximity Read ↗

CRISPR/Cas: from adaptive immune system in prokaryotes to therapeutic weapon against immune-related diseasesSemantic proximity Read ↗

The CRISPR-Cas immune system: biology, mechanisms and applications.Semantic proximity Read ↗

AcrIIA5 Inhibits a Broad Range of Cas9 Orthologs by Preventing DNA Target CleavageSemantic proximity Read ↗

Potential Use of CRISPR/Cas13 Machinery in Understanding Virus–Host InteractionSemantic proximity Read ↗

Diversity of CRISPR-Cas immune systems and molecular machines.Semantic proximity Read ↗

Self versus non-self discrimination during CRISPR RNA-directed immunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.