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Generation of hypoimmunogenic universal iPSCs through HLA-type gene knockout

2024-07-03

Abstract excerpt

<title>Abstract</title> <p>Hypoimmunogenic universal induced pluripotent stem cells (iPSCs) were generated through the targeted disruption of key genes, including human leukocyte antigen (<italic>HLA</italic>)-<italic>A</italic>, <italic>HLA-B</italic>, and <italic>HLA-DR alpha</italic> (<italic>DRA</italic>), using the CRISPR/Cas9 system. This approach aimed to minimize immune recognition and enhance the potenti...

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Literature Corpus work: 8ae9b051-9797-5822-b710-e6f1f38b49aa
DOI: 10.21203/rs.3.rs-4354435/v1

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