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B2M gene knockout in HEK293T cells by non-viral delivery of CRISPR-Cas9 for the induction of universal cell

2021-06-07

Abstract excerpt

Allogeneic stem cells have been introduced as a potential approach to generate grafts in regenerative medicine. But the clinical usage of them is limited due to the risk of immune rejection that is induced by the incompatibility of human leukocyte antigens (HLAs) between donors and recipients. To overcome this limitation, we knocked out the β2 microglobulin (B2M) gene which is crucial for HLA class I expression, u...

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Literature Corpus work: 5fb79dde-765b-5bc1-a271-c52c7df4e2eb
DOI: 10.21203/rs.3.rs-595457/v1

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