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Generation of hypoimmunogenic human pluripotent stem cells

30 Apr 2019

Abstract excerpt

Significance To enable cell therapy on a broader scale, the development of universal donor stem cell products that can be administered to multiple patients in need has been proposed, yet a strategy controlling both adaptive and innate immune rejection has not been reported. In this study, we employed multiplex genome editing to selectively ablate the highly polymorphic HLA class Ia and class II molecules and...

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PMID: 31040209
DOI: 10.1073/pnas.1902566116

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