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Derivation of induced pluripotent stem cells line (RCPCMi007-A-1) with inactivation of the beta-2-microglobulin gene by CRISPR/Cas9 genome editing

30 Jun 2021

Abstract excerpt

The mismatch of HLA haplotypes between donor and recipient adversely affects the outcome of tissue transplantation. The B2M gene knockout (B2M-KO) disrupts the HLA I heterodimer formation; therefore, B2M-KO cells have reduced immunogenicity to allogeneic CD8+ T cells. Thus, the B2M-KO IPSCs and their derivatives can potentially solve a problem of the immunological compatibility in allogeneic transplantations....

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PMID: 34237591
DOI: 10.1016/j.scr.2021.102451

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