Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Obesity-driven mitochondrial dysfunction in human adipose tissue-derived mesenchymal stem/stromal cells involves epigenetic changes

1 Jun 2024

Abstract excerpt

Obesity exacerbates tissue degeneration and compromises the integrity and reparative potential of mesenchymal stem/stromal cells (MSCs), but the underlying mechanisms have not been sufficiently elucidated. Mitochondria modulate the viability, plasticity, proliferative capacity, and differentiation potential of MSCs. We hypothesized that alterations in the 5-hydroxymethylcytosine (5hmC) profile of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Diet and metabolism studies
Share to Mesenchymal stem cell research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38824145
DOI: 10.1038/s41419-024-06774-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Obesity-driven mitochondrial dysfunction in human adipose tissue-derived mesenchymal stem/stromal cells involves epigenetic changesPMID 38824145Read ↗

Metabolic Syndrome Induces Epigenetic Alterations in Mitochondria-Related Genes in Swine Mesenchymal Stem CellsSemantic proximity Read ↗

Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cellsSemantic proximity Read ↗

Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cellsSemantic proximity Read ↗

Characterization of the Mitochondrial Genome Landscape in MSCs, iPSCs and iMSCs from Osteoarthritis Patients and Healthy DonorsSemantic proximity Read ↗

The Impact of Obesity on Autophagy in Human Adipose-Derived Mesenchymal Stromal CellsSemantic proximity Read ↗

Mitochondrial alteration in type 2 diabetes and obesity: An epigenetic linkSemantic proximity Read ↗

Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjectsSemantic proximity Read ↗

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetesSemantic proximity Read ↗

Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic DysfunctionSemantic proximity Read ↗

Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetesSemantic proximity Read ↗

Aging and Obesity Prime the Methylome and Transcriptome of Adipose Stem Cells for Disease and DysfunctionSemantic proximity Read ↗

Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogrammingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.