Article

GLDADec: marker-gene guided LDA modelling for bulk gene expression deconvolution

2024-01-09

Abstract excerpt

Inferring cell type proportions from bulk transcriptome data is crucial in immunology and oncology. Here, we introduce GLDADec (Guided LDA Deconvolution), a bulk deconvolution method that guides topics using cell type-specific marker gene names to estimate topic distributions for each sample. Through benchmarking using blood-derived datasets, we demonstrate its high estimation performance and robustness. Moreover,...

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Literature Corpus work: 8ad54a98-9183-546e-9d87-c4313e0d42fd
DOI: 10.1101/2024.01.08.574749

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