Article

BLEND: Probabilistic Cellular Deconvolution with Automated Reference Selection

2024-08-06

Abstract excerpt

Cellular deconvolution aims to estimate cell type fractions from bulk transcriptomic and other omics data. Most existing deconvolution methods fail to account for the heterogeneity in cell type-specific (CTS) expression across bulk samples, ignore discrepancies between CTS expression in bulk and cell type reference data, and provide no guidance on cell type reference selection or integration. To address these issu...

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Literature Corpus work: e95c035c-9e1c-5877-9cfa-c87cd821e808
DOI: 10.1101/2024.08.02.606458

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