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SLC16A3 Drives Lung Adenocarcinoma Progression and Gefitinib Resistance through Coordinated Regulation of Ferroptosis and Lactate Metabolism

2025-06-16

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<title>Abstract</title> <p>Background Ferroptosis is an iron-dependent form of regulated cell death that plays a critical role in tumor suppression and therapy response. However, the metabolic mechanisms that drive ferroptosis resistance in lung adenocarcinoma (LUAD), particularly in the context of EGFR-TKI tolerance, remain unclear. Methods We integrated transcriptomic and clinical data from the TCGA LUAD coho...

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Literature Corpus work
8aa427b1-c1af-595d-85c2-5b5d942f7ed7
DOI
10.21203/rs.3.rs-6833528/v1
Open publication

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SLC16A3 Drives Lung Adenocarcinoma Progression and Gefitinib Resistance through Coordinated Regulation of Ferroptosis and Lactate MetabolismDOI 10.21203/rs.3.rs-6833528/v1
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