Article

cellGeometry: ultra-fast single-cell deconvolution of bulk RNA-Seq using a geometric solution

2026-01-26

Abstract excerpt

Single-cell analysis has rapidly expanded to produce cell atlases encompassing all human tissues. However, computational methods to deconvolute bulk samples using single-cell reference data have failed to keep pace with the increasing data size. Here we present cellGeometry, which uses non-negative geometric deconvolution (NGD), an intuitive vector projection method featuring non-negative matrix regularisation. Us...

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Literature Corpus work: 8aa000e0-a02e-5f84-b3c1-843e7607e054
DOI: 10.64898/2026.01.24.701240

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