Article

SPOTlight: Seeded NMF regression to Deconvolute Spatial Transcriptomics Spots with Single-Cell Transcriptomes

2020-06-04

Abstract excerpt

The integration of orthogonal data modalities greatly supports the interpretation of transcriptomic landscapes in complex tissues. In particular, spatially resolved gene expression profiles are key to understand tissue organization and function. However, spatial transcriptomics (ST) profiling techniques lack single-cell resolution and require a combination with single-cell RNA sequencing (scRNA-seq) information to...

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Literature Corpus work: 4f4b9622-62ca-52e5-b589-d4463c51b234
DOI: 10.1101/2020.06.03.131334

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