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Article

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes.

Leukemia - 1 Nov 2018

Hosseini Mona M, Kurtz Stephen E, Abdelhamed Sherif, Mahmood Shawn, Davare Monika A, Kaempf Andy, Elferich Johannes, McDermott Jason E, Liu Tao, Payne Samuel H, Shinde Ujwal, Rodland Karin D, Mori Motomi, Druker Brian J, Singer Jack W, Agarwal Anupriya

Abstract excerpt

Interleukin-1 receptor-associated kinase 1 (IRAK1), an essential mediator of innate immunity and inflammatory responses, is constitutively active in multiple cancers. We evaluated the role of IRAK1 in acute myeloid leukemia (AML) and assessed the inhibitory activity of multikinase inhibitor pacritinib on IRAK1 in AML. We demonstrated that IRAK1 is overexpressed in AML and provides a survival signal to AML cells....

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Source

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Identifiers

PMID: 29743719
DOI: 10.1038/s41375-018-0112-2
PMCID: PMC6558520

Genes

IRAK1
FLT3
JAK2
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes.PMID 29743719Read ↗

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