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Article

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

3 Apr 2020

Abstract excerpt

Abstract Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3 inflammasome activation in murine and human cells. Mice expressing active KrasG12D in the hematopoietic system developed...

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PMID: 32246016
DOI: 10.1038/s41467-020-15497-1

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