Article

Multiplex Portuguese Families as a Lens into rare mutations and the Shared Genetic Architecture of Schizophrenia, Mood Disorders, and Autism Spectrum Disorders

2026-04-07

Abstract excerpt

In an analysis of 173 multiplex families from the Portuguese Island Collection (PIC) this study characterizes the shared genetic architecture of serious mental illnesses (SMI) including schizophrenia (SZ) , bipolar disorder (BP) , major depression (MDD) , and autism (ASD) . Within this cohort, co-segregation of psychotic and mood disorders occurred in 28% of families, while 7% demonstrated co-segregation of...

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Literature Corpus work: 8a5b8cb3-c205-587d-9abc-de15783e0063
DOI: 10.64898/2026.04.06.26350177

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