Article
The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders.
Molecular psychiatry - 1 Mar 2022
Alkelai Anna, Greenbaum Lior, Docherty Anna R, Shabalin Andrey A, Povysil Gundula, Malakar Ayan, Hughes Daniel, Delaney Shannon L, Peabody Emma P, McNamara James, Gelfman Sahar, Baugh Evan H, Zoghbi Anthony W, Harms Matthew B, Hwang Hann-Shyan, Grossman-Jonish Anat, Aggarwal Vimla, Heinzen Erin L, Jobanputra Vaidehi, Pulver Ann E, Lerer Bernard, Goldstein David B
Abstract excerpt
Schizophrenia has a multifactorial etiology, involving a polygenic architecture. The potential benefit of whole genome sequencing (WGS) in schizophrenia and other psychotic disorders is not well studied. We investigated the yield of clinical WGS analysis in 251 families with a proband diagnosed with schizophrenia (N = 190), schizoaffective disorder (N = 49), or other conditions involving psychosis (N = 48)....
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