Article

IGFs regulate cancer cell immune evasion in prostate cancer

2024-12-06

Abstract excerpt

Insulin-like growth factor-1 (IGF-1) promotes prostate cancer (PCa) development and lethality, with immunosuppressive properties in other disease models. These studies investigated the tumor-intrinsic immune effects of IGF-1 in PCa to understand mechanisms underlying its poor immunotherapy response. Transcriptional profiling of human (DU145, 22Rv1) and murine (Myc-CaP) PCa cells revealed, through pathway enrichmen...

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Literature Corpus work: 8a2bf20a-cb1a-5239-8f02-1b7a13d88a7a
DOI: 10.1101/2024.12.03.626600

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