Article

Quantitative MHC class-I/-II gene expression levels in <i>CDK12</i> mutated prostate cancer reveal intratumorally T cell adaptive immune response in tumors

2022-04-16

Abstract excerpt

<h4>Background</h4> CDK12 inactivation is a predictive biomarker for immune checkpoint blockers (ICB) treatment response in advanced prostate cancer (PCa), but some CDK12-altered patients fail to respond to ICB. Downregulation of MHC expression has been described as a mechanism of intrinsic and acquired resistance to ICB in various cancers, but there is little information on whether MHC expression levels are alte...

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Literature Corpus work: fde042e2-ba2d-584e-9f76-aae64c1507a2
DOI: 10.1101/2022.04.16.487364

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