Article

MicroRNA expression profile of fibro-adipogenic progenitors in Duchenne muscular dystrophy reveals dysregulation of adipogenesis-related microRNAs

2026-08-14

Abstract excerpt

<title>Abstract</title> <p> Background Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration and replacement of muscle fibers with fat and fibrotic tissue. Intramuscular fat deposition negatively impacts muscle function and regeneration. Fibro-adipogenic progenitors (FAPs) drive this fat deposition and fibrosis by differentiating into adipocytes and fibroblasts. Recent studies ha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a279eec-a224-5f6b-8aee-2e7d55e38f8e
DOI: 10.21203/rs.3.rs-10576032/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA expression profile of fibro-adipogenic progenitors in Duchenne muscular dystrophy reveals dysregulation of adipogenesis-related microRNAsDOI 10.21203/rs.3.rs-10576032/v1Read

The FibromiR miR-214-3p Is Upregulated in Duchenne Muscular Dystrophy and Promotes Differentiation of Human Fibro-Adipogenic Muscle ProgenitorsSemantic proximity Read

Muscle-specific microRNAs as biomarkers of Duchenne Muscular Dystrophy progression and response to therapiesSemantic proximity Read

Single cell RNA sequencing of human FAPs reveals different functional stages in Duchenne muscular dystrophySemantic proximity Read

Late-Stage Skeletal Muscle Transcriptome in Duchenne muscular dystrophy shows a BMP4-Induced Molecular SignatureSemantic proximity Read

Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in Duchenne muscular dystrophySemantic proximity Read

Small RNAome profiling from human skeletal muscle: novel miRNAs and their targets associated with cancer cachexiaSemantic proximity Read

MicroRNA-Based Therapeutic Perspectives in Myotonic DystrophySemantic proximity Read

Muscle cell atrophy induced by miR-155-5p reveals molecular targets in skeletal muscle disordersSemantic proximity Read

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their “virtual” secretomeSemantic proximity Read

The Role of MicroRNA in the Pathogenesis of Duchenne Muscular DystrophySemantic proximity Read

Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic MusclesSemantic proximity Read

Noncoding RNAs: emerging players in muscular dystrophies.Semantic proximity Read