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Article

Muscle-specific microRNAs as biomarkers of Duchenne Muscular Dystrophy progression and response to therapies

1 Jan 2014

Abstract excerpt

Recent studies have revealed the contribution of fibro-adipogenic progenitors (FAPs) to the pathogenesis and progression of Duchenne Muscular Dystrophy (DMD). While FAPs direct compensatory regeneration at early stages of disease, as the disease progresses they contribute to the progressive replacement of contractile myofibers with fibrotic scars and fatty infiltration. Using the mouse model of DMD - the mdx mice...

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PMID: 26942105
DOI: 10.4161/21675511.2014.974969

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