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Article

Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles

1 May 2020

Abstract excerpt

Fibrosis and fat replacement in skeletal muscle are major complications that lead to a loss of mobility in chronic muscle disorders, such as muscular dystrophy. However, the in vivo properties of adipogenic stem and precursor cells remain unclear, mainly due to the high cell heterogeneity in skeletal muscles. Here, we use single-cell RNA sequencing to decomplexify interstitial cell populations in healthy and...

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PMID: 32375047
DOI: 10.1016/j.celrep.2020.107597

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