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Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity

2025-06-25

Abstract excerpt

The paravertebral sympathetic chain ganglia (SCG) are autonomic ganglia critical for regulating the “fight-or-flight” response. Symptoms of sympathetic dysfunction are prevalent in diabetes, affecting up to 90% of patients. The molecular and cellular composition of the human SCG and its alteration in diabetes remains poorly defined. To address this gap, we performed spatial transcriptomic profiling of lumbar SCGs...

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Literature Corpus work
5cb36530-23a0-55d4-b69c-71bfc5475901
DOI
10.1101/2025.06.24.661373
Open publication

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Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticityDOI 10.1101/2025.06.24.661373
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