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The Development of Mechanical Allodynia in Diabetic Rats Revealed by Single-Cell RNA-Seq

20 May 2022

Abstract excerpt

Mechanical allodynia (MA) is the main reason that patients with diabetic peripheral neuropathy (DPN) seek medical advice. It severely debilitates the quality of life. Investigating hyperglycemia-induced changes in neural transcription could provide fundamental insights into the complex pathogenesis of painful DPN (PDPN). Gene expression profiles of physiological dorsal root ganglia (DRG) have been studied....

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PMID: 35668789
DOI: 10.3389/fnmol.2022.856299

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